OUR NEW PROFILE IS: (NASDAQ: THAR)
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WHEN WE LOOKED AT THIS ONE BACK IN FEB IT RAN OVER 100% IN JUST 6 SESSIONS
THAR HAS A FLOAT OF JUST UNDER 12 MILLION RIGHT NOW
READ THE INVESTOR PRESENTATION HERE
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Hello Everyone,
We have another profile for you to watch pull up immediately and watch for the rest of todays session.
This is a Biotech that trades on the Nasdaq and is sitting under .20 as we speak.
This one has a 52 week high of 2.65, so it is safe to say there is massive upside from it’s current levels under the right conditions.
Pull up THAR Immediately.
Tharimmune, Inc. is a biotechnology company developing a portfolio of therapeutic candidates for rare immune, inflammatory, and oncologic diseases. The Company is progressing towards acquiring a clinical-stage asset, known to suppress chronic, debilitating pruritis or “uncontrollable itching” in primary biliary cholangitis (PBC), a rare orphan liver disease with no known cure. The Company’s early-stage immuno-oncology pipeline includes novel multi-specific antibodies targeting unique epitopes with novel mechanisms of action against well-known, validated targets in multiple solid tumors. Tharimmune has a license agreement with OmniAb, Inc. to access the company’s antibody discovery technology platform against specified targets.
HILLSTREAM BIOPHARMA PROGRESSING TOWARDS ACQUIRING CLINICAL STAGE ASSET AND ANNOUNCES CORPORATE NAME CHANGE TO THARIMMUNE, INC.
September 22, 2023
Expects to launch and complete a Phase 1 trial in Q4 2023
Tharimmune to begin trading under new ticker, THAR, on Monday September 25, 2023
BRIDGEWATER, NJ / ACCESSWIRE / September 22, 2023 / Hillstream BioPharma Inc., (NASDAQ:HILS), a biotechnology company developing innovative therapeutic candidates in rare immune, inflammatory and oncologic diseases announced a corporate name change to Tharimmune, Inc., (“Tharimmune”). The corporate name change is based on the Greek word “thárros“, translated to mean courage and reflects the transformation of the Company into a patient-focused, clinical development organization. The Company’s common stock will trade on The Nasdaq Capital Market under a new ticker symbol, THAR, effective as of Monday, September 25, 2023.
“Over the past few months, we have made significant progress in shifting the focus of the Company to align with our future vision to impact patients in serious need of new treatment options,” said Randy Milby, Chairman and CEO of Tharimmune, Inc. Our new name, dedicated to the courage of all people diagnosed with diseases of high unmet need, aligns with this focus as we shift into a patient-centric organization striving towards developing impactful and accessible products.”
Tharimmune is progressing towards acquiring a clinical stage asset, TH104, with a recently approved IND. TH104 has a dual mechanism of action by affecting multiple receptors, known to suppress chronic, debilitating pruritis or “uncontrollable itching”. The Company expects to close the acquisition in the fourth quarter as well launch and complete a phase 1 pharmacokinetic trial by year-end. The clinical data package is strengthened by the phase 1 clinical trials already conducted ex-US, which showed reliable bioavailability of the active ingredient in TH104 via transmucosal film technology in both healthy volunteers as well as people diagnosed with liver disease, including primary biliary cholangitis.
HILLSTREAM ENTERS INTO AN EXCLUSIVE OPTION AGREEMENT TO ACQUIRE A CLINICAL STAGE ASSET FOR CHRONIC PRURITIS
Anticipate completion of Phase 1 & Phase 2 clinical trials in chronic pruritis over the next approximately 12 months
Seeking first approval in an orphan disease, PBC, for the treatment of moderate to severe chronic pruritis in which more than 70% of patients suffer from chronic pruritis
BRIDGEWATER, N.J., Sept. 11, 2023 (GLOBE NEWSWIRE) — Hillstream BioPharma, Inc. (Nasdaq: HILS) (“Hillstream” or the “Company”), a biotechnology company developing therapeutic candidates targeting drug resistant and devastating cancer announces an exclusive option agreement to acquire a clinical stage asset, AV104, with a recently approved IND. AV104 has a dual mechanism of action by affecting multiple receptors, known to suppress chronic, debilitating pruritis or “uncontrollable itching”. The Company intends to first seek approval in an orphan disease for the treatment of moderate to severe cholestatic pruritis in patients with primary biliary cholangitis (PBC), a rare form of liver disease with no known cure in which more than 70% of patients suffer from chronic pruritis.
Embedded onto a proprietary transdermal buccal film which easily adheres to the inside of the mouth, AV104’s key features make it an ideal product candidate for multiple liver-related and other pruritogenic inflammatory conditions. AV104’s active molecule, nalmefene, has a dual mechanism of action by affecting both the µ-opioid receptor and the kappa opioid receptor as well as inhibiting IL-17 inflammatory cytokine expression. These opioid receptors when stimulated and/or inhibited by the body’s natural ligands have been known to be involved in the body’s itch circuitry.
When the itch circuitry is imbalanced in diseased conditions, pharmacological intervention can help suppress this phenomenon which occurs in patients suffering from chronic pruritis. Nalmefene crosses into the circulation via a proprietary buccal delivery by adhering the drug-coated film inside the cheek where the film biodegrades in minutes and the drug is absorbed. The buccal delivery of the drug bypasses the liver’s first-pass metabolism thus creating high drug concentrations in the skin, an added benefit for treating conditions in which the liver may be impaired. The Company intends to complete a bridging pharmacokinetic phase 1 trial and a phase 2 proof-of-concept in PBC patients over approximately the next 12 months after alignment with the US FDA.
Hillstream believes AV104 has expansion opportunities in treating chronic pruritogenic conditions associated with cholestatic liver disease as well as other liver related and as non-liver related diseases including fatty and alcoholic liver diseases, non-alcoholic liver diseases and certain types of hepatitis. Chronic pruritis is significant in liver diseases as well as chronic kidney diseases, hemodialysis and atopic dermatitis.
“The past year has been a period of transformational change for our company,” said Randy Milby, CEO of Hillstream. “This exclusive option allows the company to bring a clinical-stage asset into the organization as we shift into a patient-focused biotechnology organization. This signifies our next step as we grow into a business model focused on clinical development.”
Webcast details
Hillstream BioPharma will host a webcast on Monday September 11 th at 4:30 pm ET to describe this opportunity in more detail.
Participant Dial-In: 877-407-8835 / +1 201-689-8779. Click here for participant International Toll-Free access numbers
Webcast: https://event.webcasts.com/starthere.jsp?ei=1633694&tp_key=3823baed9e
THE HILLSTREAM BIOPHARMA PIPELINE
HSB-3215: ANTI-HER2/HER3 BISPECIFIC AB
The ErbB family of cell surface proteins are some of the most well-known and validated oncology drug targets including ErbB2 or HER2 (human epidermal growth factor receptor) and Erb3 or HER3. The family of antibodies and biologics against HER2 starting with HERCEPTIN® (trastuzumab) approved in 1998 for breast cancer, one of the first few anti-cancer antibodies, as well as PERJETA®, KADCYLA® and PHESGO® totaled $8.4 billion in 2022 sales for Roche/Genentech. Antibodies against HER2 and HER3 bind to different domains of the extracellular portion of the proteins or epitopes with trastuzumab binding domain IV of HER2 primarily. HER2 is also one of the most utilized targeting antigens for antibody drug conjugates to treat HER2 positive cancers with two approved antibodies, Roche/Genentech’s PERJETA® and Daiichi Sankyo/AstraZeneca’s ENHERTU®.
The Applied Biomedical Science Institute has developed technology to target unique functional epitopes of the cancer targets HER2 and HER3. Monoclonal antibodies being developed at ABSI are unique from the currently approved anti-HER2 antibodies. ABSI has granted under an exclusive option agreement to Hillstream, certain of its proprietary technology which if converted to an exclusive license agreement, will allow Hillstream to develop HER2 and HER3 antibodies, including multi-specific and Quatramer- based therapeutics incorporating portions of the antibodies.
HSB-0059: BISPECIFIC ADC
Antibody Drug Conjugates (ADCs) are a class of newly emerging therapeutics which may serve as “magic bullets” to treat certain cancers. They consist of a 1) a cancer killing chemotherapeutic payload, 2) an antibody-targeting a cancer cell and 3) a linker connecting the antibody to the payload. The problem with some ADCs targeting HER2 and/or HER3 essentially target the same epitopes as trastuzumab based domains. Our solution based on data an HSB-3215 (HER2/HER3) mAb backbone with HSB-0059 targets novel epitopes on HER2 while blocking natural ligands to HER3 and/or preventing heterodimers. ADCs can also have a potential “bystander effect” of its’ toxin payload. We intend to design ADCs whereby the toxin delivered to surrounding non-antigenic cancer tissue can be killed and maximize antitumor potential for this novel compound.
HSB-1940: ANTI-PD-1 (UNDRUGGABLE EPITOPES)
Picobodies are antibody “knob” domains comprised of cysteine-rich ultralong complementary determining region (CDR) H3 sequences of 30-40 amino acids, which have the potential to access challenging epitopes better than full size antibodies can. By combining Quatramers with their long half-life coated with a PD-1 Picobody™ to create HSB-1940, we intend to efficiently target novel epitopes with greater binding affinity than approved biologics.
Antibodies derived from mouse or human sources use the surface formed by complementarity determining regions (CDRs) on the variable regions of the heavy chain/light chain heterodimer, which typically forms a relatively flat binding surface. Alternative species, particularly camelids and bovines, provide a paradigm for antigen recognition through novel domains which form the antigen binding site. However, for camelids, heavy chain antibodies bind antigen with only a single heavy chain variable region, in the absence of light chains. Meanwhile, in bovines, ultralong CDR-H3 regions form an independently folding mini-domain, which protrudes far out from the surface of the antibody and forms a “stalk and knob” structure which is diverse in both its sequence and disulfide patterns. The “knob” (Picobody) component can be expressed as an independent antigen binding domain. At ~4-6 kDa, these are three times smaller than a camelid “nanobody”, and are the smallest known antibody fragment. These atypical antigen binding sites of bovines potentially provide the ability to interact with different antigenic determinants, particularly recessed or concave surfaces, compared to traditional antibodies.
NEWS
FRI SEP 22ND, 2023
- HILLSTREAM BIOPHARMA PROGRESSING TOWARDS ACQUIRING CLINICAL STAGE ASSET AND ANNOUNCES CORPORATE NAME CHANGE TO THARIMMUNE, INC.
THU SEP 21ST, 2023
- DAWSON JAMES SECURITIES ANNOUNCES OCTOBER DATE FOR 8TH ANNUAL SMALL CAP GROWTH CONFERENCE
MON SEP 11TH, 2023
- HILLSTREAM ENTERS INTO AN EXCLUSIVE OPTION AGREEMENT TO ACQUIRE A CLINICAL STAGE ASSET FOR CHRONIC PRURITIS
FRI SEP 8TH, 2023
- HILLSTREAM BIOPHARMA TO PRESENT AT H.C. WAINWRIGHT 25TH ANNUAL GLOBAL INVESTMENT CONFERENCE SEPTEMBER 11-13
WED AUG 9TH, 2023
- HILLSTREAM BIOPHARMA TO PRESENT AT THE SIDOTI MICRO-CAP VIRTUAL CONFERENCE ON AUGUST 16-17, 2023
THU JUL 20TH, 2023
- HILLSTREAM ADVANCES NEXT-GEN MULTISPECIFIC ANTIBODIES FOR SOLID TUMORS WITH LEAD HER2/HER3 PROGRAM, HSB-3215
MON JUL 10TH, 2023
- HILLSTREAM BIOPHARMA ANNOUNCES STRATEGIC REPRIORITIZATION OF PIPELINE TO TARGETING HER2/HER3 SOLID TUMORS VIA BISPECIFIC AND ADC ANTIBODIES AND BIOLOGICS
THU JUL 6TH, 2023
- HILLSTREAM BIOPHARMA LICENSES TECHNOLOGY TO DEVELOP PROPRIETARY HER2 AND HER3 ANTIBODY DRUG CONJUGATES AGAINST DRUG-RESISTANT BREAST, LUNG, GASTRIC, AND OVARIAN CANCERS
MON MAY 15TH, 2023
- HILLSTREAM BIOPHARMA STRENGTHENS ITS BOARD OF DIRECTORS WITH APPOINTMENT OF KELLY ANDERSON
TUE MAY 2ND, 2023
- HILLSTREAM BIOPHARMA ANNOUNCES CLOSING OF PUBLIC OFFERING OF COMMON STOCK
MANAGEMENT
RANDY MILBY – CEO & CHAIRMAN
Mr. Milby was the former Chief Executive Officer and Member of the Board of Directors at CorMedix, a publicly traded biopharmaceutical company focused on developing and commercializing therapeutic products for the prevention and treatment of inflammatory and infectious diseases. A seasoned executive who led the increase in market capitalization from $3M to a peak of $350M of Cormedix while improving the company’s financial position with capital raises from equity markets. He oversaw efforts to gain CE Market approval of Neutrolin® in the European Union and held increasing roles of responsibility at Goldman Sachs and Dupont Merck prior in his career.
SIREESH APPAJOSYULA, PHARMD – CHIEF OPERATING OFFICER
Sireesh Appajosyula joined as COO in July of 2023 and has served as a member of our board of directors since July 2021. Previously, he was SVP, Corporate Development and Operations of 9 Meters Biopharma, a company focused on rare and unmet needs and is Managing Member of Highpoint Pharmaceuticals, LLC, a pharmaceutical research and development company. In addition, since 2015, Mr. Appajosyula has served as Managing Partner of Channel BioConsulting, LLC, a company that assists in enhancing search and evaluation efforts for complementary assets to be added to existing portfolios of biopharmaceutical companies. Prior to 9 Meters, Mr. Appajosyula was at Salix Pharmaceuticals, Inc. (“Salix”) (Nasdaq: SLXP) in various roles in medical affairs, product commercialization and business development until its acquisition by Bausch Health (Nasdaq: BHC). Prior to Salix, he was involved in various roles at Amgen Inc., Critical Therapeutics, Inc. (now Chiesi) and Sanofi (formerly Aventis). Mr. Appajosyula received his Bachelor of Science and Doctor of Pharmacy from Rutgers University.
THOMAS HESS CPA – CHIEF FINANCIAL OFFICER
Thomas Hess is an experienced financial expert. From August 2014 until June 2021, Mr. Hess served as Chief Financial Officer and Senior Vice President of Finance of Genomind, Inc., a mental health company that developed and sold a pharmacogenomic test that analyzed how an individual’s genes may affect medication outcomes. From September 2011 until its sale in April 2014, Mr. Hess served as Chief Financial Officer and Executive Vice President of Finance of The Keane Organization, a comprehensive provider of unclaimed property services. Mr. Hess also previously served in various other capacities including, but not limited to, Chief Financial Officer and Senior Vice President of Yaupon Therapeutics, Inc.; Chief Financial Officer and Vice President, Finance of Adolor Corporation; Corporate Controller of Vicuron Pharmaceuticals, Inc.; and Senior Manager – Accounting and Audit of KPMG. Mr. Hess was formerly an adjunct faculty member/lecturer at Pennsylvania State University and DeSales University. Mr. Hess received his B.S. in accounting from The Pennsylvania State University and his MBA from Katz Graduate School of Business, University of Pittsburgh. Mr. Hess is a Certified Public Accountant in the state of Pennsylvania. He currently serves on the Alumni Council of Penn State and is the Chairman of the Nittany Lion Club Annual Fund.
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